November 18, 2015
Dr. Cedric Rentier awarded for the best Young Investigator Oral Presentation at the 52nd Japanese Peptide Symposium
Dr. Cedric Rentier obtained the Award for the best Young Investigator Oral Presentation at the 52nd Japanese Peptide Symposium (Chuo Community Center, Hiratsuka, 16-18 November 2015) presenting the results of his PhD obtained on July 2015 from the PhD School of the University of Cergy-Pontoise cotutored with the PhD School in Chemical Sciences of the University of Florence.
Title of the presentation awarded: "Peptides of the dihydrolipoamide acetyltransferase as synthetic probes of autoantibodies in primary biliary cirrhosis"
The PeptLab community congratulates Cedric!
Anna Maria Papini Laureate of the ANR Chaire d'Excellence Senior Longue durée 2009 - Project “PepKit: Development of peptide-based kits for autoimmune diseases”
The Project “PepKit: Development of peptide-based kits for autoimmune diseases” developed by the Laureate Anna Maria Papini who was awarded in 2009 with the "Chaire d'Excellence" ANR-09-CEXC-013-01, was accomplished on September 30, 2014, after a five-year project.
The original approach termed Chemical Reverse Approach that A.M. Papini proposed (J.Pept.Sci. 2009, 15, 621) aims to design, synthetize and validate in biological fluids of patients, molecules involved in the molecular mechanisms of immune-mediated diseases.
The most relevant results of this five-year project were the development of 6 innovative tests:
1) PHTALOX Test to detect in urines the metabolites of di-(2-ethylhexyl) phthalate (MEHP, 6-OH-MEHP, 5-oxo-MEHP, 5-OH-MEHP et 5-CXMEHP) to measure by RP-HPLC-ESI-MS. We demonstrated that this test was useful to characterize autistic children (in cooperation with J. Hayek, Children Neuropsychiatry, Siena University Hospital, IT) and metabolic dysfunctions linked to obesity and insulin resistance in children (in cooperation with M. Street, Pediatric Modena and Reggio Emilia University Hospital, IT).
2) Electro-MSPepKit, a microfluidic test based ona new detection method based on the electrochemical technology of C. Amatore (ENS, Paris) to detect specific autoantibodies in Multiple Sclerosis in a few microliter of serum, alternative to SP-ELISA. New Glaser cyclized glycopeptide probes for Multiple Sclerosis were developed in cooperation with S. Lavielle and J.-M. Mallet (ENS/UPMC, Paris).
3) Multiplex-PepKit to detect new autoantibodies, different from anti-AQP4, to characterize Neuromyelitis Optica (in cooperation with J. de Seze, INSERM & Université de Strasbourg).
4) N-Glc-PepKit, a test to characterise an immune dysfunction in the rare Rett Syndrome (in cooperation with J. Hayek and C. De Felice, Children Neuropsychiatry, Siena University Hospital, IT).
5) DelipoPDH-PepKit, an SP-ELISA to study the role of delipoylation of the E2 complex of Pyruvate Dehydrogenase in autoantibodies from patients affected by Primary Biliary Cirrhosis (in cooperation with C.F. Selmi & P.M. Battezzati, Humanitas Research Hospital, Rozzano, IT).
6) ClickCancer pretargeting via “clicked” peptidomimetic probes targeting over-expressed receptors in cancer forms in cooperation with F. Denat (Institut de Chimie Moléculaire de l’Université de Bourgogne, Dijon, France) and M. Chorev (Harvard Medical School, Cambridge, MA, US).
The most relevant outcome is the establishment of the platform PeptLab@UCP located at Neville site of the University of Cergy-Pontoise and joined to the PeptLab@Unifi Interdepartmental Laboratory of the University of Florence by a formal cultural, scientific and research agreement signed by the Rector of the University of Florence and the President of the University of Cergy-Pontoise.
The Perspective is the organization of a Virtual European Infrastructure of PeptLab (www.peptlab.eu) to support research and development of diagnostics of molecules in any matrix (biological fluids, nutraceutics, environment, cosmetics, etc.) in the interest of a reliable Molecular Detection for Life Sciences - MoDeLS.