Doi: 10.1016/j.jpba.2020.113775.


Susceptibility of cosmeceutical peptides to proteases activity: development of dermal stability test by LC-MS/MS analysis.

F. Errante; M. Menicatti; M. Pallecchi; L. Giovannelli; A.M. Papini; P. Rovero, G. Bartolucci. Journal of Pharmaceutical and Biomedical Analysis 2020

doi: 10.1016/j.cca.2021.01.002


Cross-reactive peptide epitopes of Enterovirus Coxsackie B4 and human glutamic acid decarboxylase detecting antibodies in Latent Autoimmune Diabetes in Adults versus Type 1 Diabetes

F. Real-Fernández, A. Gallo, F. Nuti, L. Altamore, G. Giovanna Del Vescovo, P. Traldi, E. Ragazzi, P. Rovero, A. Lapolla, A.M. Papini. Clinica Chimica Acta (2021) 515, 73-79.



An Optimised Di-Boronate-ChemMatrix Affinity Chromatography to Trap Deoxyfructosylated Peptides as Biomarkers of Glycation.

M. Kijewska, F. Nuti, M. Wierzbicka, M. Waliczek, P. Ledwon, A. Staskiewicz, F. Real-Fernandez, G. Sabatino, P. Rovero, P. Stefanowicz, Z. Szewczuk, A.M. Papini. Molecules 2020, 25, 755.

doi: 10.1002/pep2.24159


On-resin microwave-assisted copper-catalysed azide-alkyne cycloaddition of H1-relaxin B single chain “stapled” analogues.

A. D’Ercole, G. Sabatino, L. Pacini, E. Impresari, I. Capecchi, A.M. Papini, P. Rovero. Peptide Science 2020; 112(4); 1-10, e24159.


Triterpene glycosides from Blighia welwitschii and evaluation of their antibody recognition capacity in multiple sclerosis. 

B. Petit, A.-C. Mitaine-Offer, F. Real-Fernández, A.M. Papini, C. Delaude, T. Miyamoto C. Tanaka, P. Rovero, M.-A. Lacaille-Dubois. Phytochemistry 2020, 176, 112392.

doi: 10.3390/brainsci10070453


A Multiple N-Glucosylated Peptide Epitope Efficiently Detecting Antibodies in Multiple Sclerosis.

Nuti, F.; Fernandez, F.R.; Sabatino, G.; Peroni, E.; Mulinacci, B.; Paolini, I.; Pisa, M.D.; Tiberi, C.; Lolli, F.; Petruzzo, M.; Lanzillo, R.; Morra, V.B.; Rovero, P.; Papini, A.M. Brain Sci. 2020, 10(7), 453.

doi: 10.1002/psc.3281


Hyper-glucosylated adhesin derived peptides as antigenic probes in multiple sclerosis: structure optimisation and immunological evaluation.

A. Mazzoleni, F. Real-Fernandez, M. Larregola, F. Nuti, O. Lequin, A.M. Papini, J.-M. Mallet, P. Rovero. . J. Pept. Sci. 2020; 1-11. e3281.

doi: 10.3390/ijms21217827


Identification of NPB, NPW and Their Receptor in the Rat Heart.

Pandey, S.; Tuma, Z.; Peroni, E.; Monasson, O.; Papini, A.M.; Chottova Dvorakova, M. Identification of NPB, NPW and Their Receptor in the Rat Heart. Int. J. Mol. Sci. 2020, 21, 7827.



Detailed insight into interaction of bicyclic somatostatin analogue with Cu(II) ions.

A. Marciniak, W. Witak, G. Sabatino, A.M. Papini, J. Brasun. Int.J.Mol.Sci. 2020, 21, 8794, 1-13.

ID: op-2020-004905.  Accepted on December 9, 2020.


An optimized scalable fully automated solid-phase microwave-assisted cGMP-ready process for the preparation of Eptifibatide. Organic Process Research & Development. 

Sabatino, G.; D'Ercole, A.; Pacini, L.; Zini, M.; Ribecai, A.; Paio, A.; Rovero, P.; Papini, A.M. 2020 In press



Cosmeceutical peptides in the framework of sustainable wellness economy.

F. Errante, P. Ledwo?, R. Latajka, P. Rovero, A.M. Papini. Front. Chem. 2020, 8:572923. Women in Science: Chemistry.



An Optimized Scalable Fully Automated Solid-Phase Microwave-Assisted cGMP-Ready Process for the Preparation of Eptifibatide

G. Sabatino, A. DErcole, L. Pacini, M. Zini, A. Ribecai, A. Paio, P. Rovero, A.M. Papini

doi: 10.1016/j.ab.2018.11.018


Detection of anti-adalimumab antibodies in a RA responsive cohort of patients using three different techniques

Real-Fernández F, Pregnolato F, Cimaz R, Papini AM, Borghi MO, Meroni PL, Rovero P. Analytical Biochemistry 2019, 566, 133-138.

doi: 10.1016/


Glycoreplica peptides to investigate molecular mechanisms of immune-mediated physiological versus pathological conditions

A. Mazzoleni, J.-M. Mallet, P. Rovero, A.M. Papini. Arch Biochem Biophys 2019, 663, 44-53. Review. Accepted on Dec. 26, 2018. Available online Dec. 27, 2018.

doi: 10.1002/psc.3142


Modeling interaction between gp120 HIV protein and CCR5 receptor

I. Guryanov, F. Real-Fernández, G. Sabatino, N. Prisco, E. Popova, V. Korzhikov-Vlakh, B. Biondi, A.M. Papini, E. Korzhikova-Vlakh, P. Rovero, T. Tennikova. J. Pept. Sci., 2019, Feb;25(2):e3142.

DOI: 10.3389/fchem.2019.00180


A photochromic azobenzene peptidomimetic of a β-turn model peptide structure as a conformational switch.

F. Nuti, C. Gellini, M. Larregola, L. Squillantini, R. Chelli, P.R. Salvi, O. Lequin, G. Pietraperzia, A.M. Papini. FRONTIERS IN CHEMISTRY. SECTION: SUPRAMOLECULAR CHEMISTRY (2019) 7, Art. 180

DOI: 10.1002/psc.3167


Just a spoonful of sugar: short glycans affects protein
properties and functions.

C. Bello, P. Rovero, A.M. Papini. J PEPT SCI 2019; 25(5), e31-67

doi: 10.1002/art.41010


Humoral response against LL-37 in psoriatic disease: comment on the article by Yuan et al. 

M. De Santis, N. Isailovic, L. Altamore, F. Real-Fernandez, E. Generali, A. Ceribelli, G. Sabatino, A.M. Papini, P. Rovero, C. Selmi. ARTHRITIS & RHEUMATOLOGY 2019; 71(11), 1964-1965.

doi: 10.1016/j.fitote.2019.104242 


Cytotoxic glycosides from the roots of Weigela x "Bristol Ruby". 

Nguyen DH, Mitaine-Offer AC, Maroso S, Papini AM, Paululat T, Bellaye PS, Collin B, Chambin O, Lacaille-Dubois MA. Fitoterapia 2019 Sep;137:104242.

PMID: 31903893


Study of Aberrant Modifications in Peptides as a Test Bench to Investigate the Immunological Response to Non-Enzymatic Glycation. 

Nuti F, Gallo A, Real-Fernandez F, Rentier C, Rossi G, Piarulli F, Traldi P, Carganico S, Rovero P, Lapolla A, Papini AM. Folia Biol (Praha) 2019; 65(4):195-202.

doi: 10.1016/j.aquaculture.2019.734403


Effect of mealworm (Tenebrio molitor L.) larvae meal on amino acid composition of gilthead sea bream (Sparus aurata L.) and rainbow trout (Oncorhynchus mykiss W.) fillets.

V. Iaconisi, G. Secci, G. Sabatino, G. Piccolo, L. Gasco, A.M. Papini, G. Parisi. Aquaculture 2019; 513, 734403.

doi: 10.1002/chem.201704307


Orthogonal ¹8F-labeling for solid-state NMR reveals the conformation and orientation of short peptaibols in membranes

Grage SL, Kara S, Bordessa A, Doan V, Rizzolo F, Putzu M, Kuba T, Papini AM, Chaume G, Brigaud T, Afonin S, Ulrich AS. Chem.Eur.J. 2018, 24(17), 4328-4335. Mar 20, 2018.

doi: 10.1002/pep2.24071


Design, Synthesis and Conformational Studies of [DOTA]-Octreotide Analogues Containing [1,2,3]Triazolyl as a Disulfide Mimetic

Chiara Testa; Debora D’Addona; Mario Scrima; Anna Maria Tedeschi; Anna Maria D’Ursi; Claire Bernhard; Franck Denat; Claudia Bello; Paolo Rovero; Michael Chorev; Anna Maria Papini. PEPTIDE SCIENCE 2018, 110(5) e24071. First published: 14 May 2018.



Antibody Epitope of human α-Galactosidase A revealed by affinity-mass spectrometry: a basis for reversing immunoreactivity in enzyme replacement therapy of Fabry Disease

Kukacka Zdenek; Iurascu Marius; Lupu Loredana; Rusche Hendrik; Murphy Mary; Altamore Lorenzo; Borri Fabio; Maeser Stefan; Papini Anna-Maria; Hennermann Julia; Przybylski Michael. CHEMMEDCHEM 2018; 13(9); 909-915.



Channel-forming activity of nisin in two mercury-supported biomimetic membranes

Becucci, Lucia; Aloisi, Giovanni; Papini, Anna Maria; Guidelli, Rolando. JOURNAL OF ELECTROANALYTICAL CHEMISTRY 2018; 812; 186-193.

doi: 10.1016/j.fitote.2018.04.017


Oleanane-type glycosides from the roots of Weigela florida "rumba" and evaluation of their antibody recognition

Champy-Tixier AS, Mitaine-Offer AC, Fernández FR, Miyamoto T, Tanaka C, Papini AM, Lacaille-Dubois MA. Fitoterapia. 2018 Apr 30. pii: S0367-326X(18)30258-2.

doi: 10.2174/1568026618666180518095755


Copper-catalyzed azide alkyne cycloaddition (CuAAC)-mediated macrocylization of peptides: impact on conformation and biological activity

Chiara Testa, Anna Maria Papini, Michael Chorev, Paolo Rovero. Curr. Topics Med. Chem 2018, 18(7), 591-610.


Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting

M.E. Street , A.M. Papini, et al. Int. J. Mol. Sci. 2018, 19(6), 1647-1690.

doi: 10.1016/


Antibodies to post-translationally modified mitochondrial peptide PDC-E2(167-184) in type 1 diabetes

Nuti F, Gallo A, Real-Fernandez F, Crulli M, Rentier C, Piarulli F, Peroni E, Rossi G, Traldi P, Rovero P, Lapolla A, Papini AM. Arch Biochem Biophys. 2018 Sep 25; 659:66-74.

doi: 10.13128/substantia-63


From morphine to endogenous opioid peptides, e.g., endorphins: the endless quest for the perfect painkiller

Anna Maria Papini. Substantia 2(2): 81-91.

doi: 10.1007/s10973-016-5387-9


Conformation-dependent affinity of Cu(II) ions peptide complexes derived from the human Pin1 protein

Dorota Uber, Dariusz Wyrzykowski, Caterina Tiberi, Giuseppina Sabatino, Wioletta Zmudzinska, Lech Chmurzynski, Anna Maria Papini, Joanna Makowska. Journal of Thermal Analysis and Calorimetry 2017, 127:2, 1431–1443.

doi: 10.3389/fchem.2017.00008


DOTA-derivatives of octreotide dicarba-analogs with high affinity for somatostatin sst2,5 rreceptors

Alessandro Pratesi, Mauro Ginanneschi, Marco Lumini, Anna Maria Papini, Ettore Novellino, Diego Brancaccio, Alfonso Carotenuto. Front Chem. 2017, 23;5:8.

doi: 10.1002/mrc.4550


Structural analysis of oleanane-type saponins from the roots of Wisteria frutescens

Anne-Sophie Champy, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Anna-Maria Papini, Marie-Aleth Lacaille-Dubois. Magnetic Resonance in Chemistry 2017, 55:6, 595–600.

doi: 10.1002/cmdc.201700042


Structure–Activity Relationship Studies, SPR Affinity Characterization, and Conformational Analysis of Peptides That Mimic the HNK-1 Carbohydrate Epitope

Ieronymaki M, Nuti F, Brancaccio D, Rossi G, Real-Fernández F, Cao Y, Monasson O, Larregola M, Peroni E, Uziel J, Sabatino G, Novellino E, Carotenuto A, Papini AM, Rovero P. ChemMedChem. 2017 May 22;12(10):751-759.

doi: 10.1016/j.cep.2017.02.005


Synthesis of dicarba-cyclooctapeptide Somatostatin analogs by conventional and MW-assisted RCM: a study about the impact of the configuration at Cα of selected amino acids. 

Pratesi A, Stazzoni S, Lumini M, Sabatino G, Carotenuto A, Brancaccio D, Novellino E, Chinol M, Rovero P, Ginanneschi M, Papini AM. Chemical Engineering & Processing 2017, 122, 365-372

ISSN: 1555-9475 (online)


Triterpene Saponins from Wisteria floribunda "macrobotrys" and "rosea"

Champy, AS; Mitaine-Offer, AC; Paululat, T; Papini, AM; Lacaille-Dubois, MA. NATURAL PRODUCT COMMUNICATIONS 2017, 12:10, 1573-1576. Published: OCT 2017

doi: 10.1517/13543776.2016.1158810


Production of peptides as generic drugs: a patent landscape of octreotide.

Sabatino G, Guryanov I, Rombecchi A, Zanon J, Ricci A, Cabri W, Papini AM, Rovero P. Expert Opin Ther Pat. 2016;26(4):485-95. Review.

doi: 10.1016/j.autrev.2016.01.011


Rett syndrome: An autoimmune disease?

De Felice C, Leoncini S, Signorini C, Cortelazzo A, Rovero P, Durand T, Ciccoli L, Papini AM, Hayek J. Autoimmun Rev. (2016) 15(4), 411-6.

doi: 10.1007/s13361-015-1321-9


Multi-Stage Mass Spectrometry Analysis of Sugar-Conjugated β-Turn Structures to be Used as Probes in Autoimmune Diseases.

Giangrande C, Auberger N, Rentier C, Papini AM, Mallet JM, Lavielle S, Vinh J. Journal of The American Society for Mass Spectrometry (2016) 27(4), 735-747.

doi: 10.1002/psc.2839


Epitope mapping of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in a mouse model of multiple sclerosis: microwave-assisted synthesis of the peptide antigens and ELISA screening.

Pacini G, Ieronymaki M, Nuti F, Sabatino G, Larregola M, Aharoni R, Papini AM, Rovero P. J Pept Sci. (2016) 22(1), 52-8.

 doi: 10.1055/s-0035-1568263


 Natural Triterpene Glycosides for Antibody Recognition

E. Peroni, F. Real Fernández, C. Gheri, F. Nuti, A.C. Mitaine-Offer, F. Lolli, M.A. Lacaille-Dubois, A.M. Papini. Planta Medica Letters (2016), 3, 1-6.

doi: 10.1038/srep39430


Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable Haemophilus influenzae.

Walvoort MT, Testa C, Eilam R, Aharoni R, Nuti F, Rossi G, Real-Fernandez F, Lanzillo R, Brescia Morra V, Lolli F, Rovero P, Imperiali B, Papini AM. Sci Rep. 2016 Dec 23;6:39430.

doi: 10.1002/cmdc.201500472


Serpin A1 C-Terminal Peptides as Collagen Turnover Modulators.

Pascarella S, Tiberi C, Sabatino G, Nuti F, Papini AM, Giovannelli L, Rovero P. CHEMMEDCHEM 2016; 11(16):1850-1855.

doi: 10.1002/psc.2761


Synthesis of diastereomerically pure lipoyl-lysine building-blocks for Fmoc/tBu solid phase synthesis of modified peptides designed for primary biliary cirrhosis diagnostics. 

C. Rentier, G. Pacini, F. Nuti, E. Peroni, P. Rovero, and A.M. Papini. J.Pept.Sci. (2015) 21 (5), 408-414.

doi: 10.1039/C4OB02685C


Design and Solid Phase Synthesis of New DOTA Conjugated (+)-Biotin Dimers Planned to Develop Molecular Weight-Tuned Avidin Oligomers. 

A. Pratesi, M. Ginanneschi, F. Melani, M. Chinol, A. Carollo, G. Paganelli, M. Lumini, M. Bartoli, M. Frediani, L. Rosi, G. Petrucci, L. Messori, and A.M. Papini. Org. Biomol. Chem. (2015) 13, 3988-4001.



Di-(2-Ethylhexyl)Phthalate Metabolites in Urine Show Age-Related Changes and Associations with Adiposity and Parameters of Insulin Sensitivity in Childhood.

A. Smerieri, C. Testa, P. Lazzeroni, F. Nuti, E. Grossi, S. Cesari, L. Montanini, G. Latini, S. Bernasconi, A.M. Papini, and M.E. Street. PLoS ONE (2015) 10(2), 1-16: e0117831. Open Access Article.

doi: 10.1021/jm5017126


Synthetic Peptides Reproducing Tissue Transglutaminase-Gliadin Complex Neo-epitopes as Probes for Antibody Detection in Celiac Disease Patients’ Sera.

M. Di Pisa, S. Pascarella, M. Scrima, G. Sabatino, F. Real Fernández, M. Chelli, D. Renzi, A. Calabrò, A.M. D'Ursi, A.M. Papini, and P. Rovero. J.Med.Chem. (2015) 58 (3), 1390–1399.



Label-free method for anti-glucopeptide antibody detection in Multiple Sclerosis.

F. Real Fernández, G. Rossi, F. Lolli, A.M. Papini, and P. Rovero. MethodsX (2015) 2, 141-144. Open Access Article.

doi: 10.1016/j.electacta.2015.07.158


Interactions between human antibodies and synthetic conformational peptide epitopes: innovative approach for electrochemical detection of biomarkers of multiple sclerosis at platinum electrodes 

W. Bellagha-Chenchaha, C. Sella, F. Real Fernandez, E. Peroni, F. Lolli, C. Amatore, L. Thouin, A.M. Papini. Electrochimica Acta, (2015) 176, 1239–1247.

doi: 10.1002/cmdc.201500472


Serpin A1 C-Terminal Peptides as Collagen Turnover Modulators.

Pascarella S, Tiberi C, Sabatino G, Nuti F, Papini AM, Giovannelli L, Rovero P. ChemMedChem. 2015 Nov 30.

doi: 10.3390/membranes5040576


Interaction Study of Phospholipid Membranes with an N-Glucosylated β-Turn Peptide Structure Detecting Autoantibodies Biomarkers of Multiple Sclerosis.

Becucci L, Benci S, Nuti F, Real-Fernandez F, Vaezi Z, Stella L, Venanzi M, Rovero P, Papini AM. Membranes (Basel). 2015 Sep 30;5(4):576-96.

doi: 10.1002/bip.22738


Peptides in Paris.

Papini AM, Lavielle S, Lubell WD; Co-editors and PIPS organizers. Biopolymers. 2015 Sep;104(5):v-vii.

doi: 10.1021/acs.jmedchem.5b00783


Role of Lipoylation of the Immunodominant Epitope of Pyruvate Dehydrogenase Complex: Toward a Peptide-Based Diagnostic Assay for Primary Biliary Cirrhosis.

Pacini G, Carotenuto A, Rentier C, Nuti F, Real-Fernandez F, Brancaccio D, Sabatino G, Larregola M, Peroni E, Migliorini P, Novellino E, Battezzati PM, Selmi C, Papini AM, Rovero P. J Med Chem. 2015 Aug 27;58(16):6619-29.

doi: 10.1007/s00216-015-8915-8


Surface plasmon resonance-based methodology for anti-adalimumab antibody identification and kinetic characterization.

Real-Fernández F, Cimaz R, Rossi G, Simonini G, Giani T, Pagnini I, Papini AM, Rovero P. Anal Bioanal Chem. 2015 Sep;407(24):7477-85.

doi: 10.1016/j.mex.2015.03.004. eCollection


Label-free method for anti-glucopeptide antibody detection in Multiple Sclerosis.

Real-Fernández F, Rossi G, Lolli F, Papini AM, Rovero P. MethodsX. 2015 Mar 12;2:141-4.

doi: 10.1002/bip.22677


Antibody recognition in multiple sclerosis and Rett syndrome using a collection of linear and cyclic N-glucosylated antigenic probes.

Real Fernández F, Di Pisa M, Rossi G, Auberger N, Lequin O, Larregola M, Benchohra A, Mansuy C, Chassaing G, Lolli F, Hayek J, Lavielle S, Rovero P, Mallet JM, Papini AM. Biopolymers (2015) Sep;104(5):560-76.

doi: 10.1517/13543776.2015.1043267


Novel diagnostic tools and solutions for multiple sclerosis treatment: a patent review (2009 - 2014).

Papini AM, König E. Expert Opin Ther Pat. (2015) 25(8):873-84.

doi: 10.1002/psc.2761


Synthesis of diastereomerically pure Lys(Nε-lipoyl) building blocks and their use in Fmoc/tBu solid phase synthesis of lipoyl-containing peptides for diagnosis of primary biliary cirrhosis.

Rentier C, Pacini G, Nuti F, Peroni E, Rovero P, Papini AM. J Pept Sci. (2015) May;21(5):408-14.

doi: 10.1039/c4ob02685c


Design and solid phase synthesis of new DOTA conjugated (+)-biotin dimers planned to develop molecular weight-tuned avidin oligomers.

Pratesi A, Ginanneschi M, Melani F, Chinol M, Carollo A, Paganelli G, Lumini M, Bartoli M, Frediani M, Rosi L, Petrucci G, Messori L, Papini AM. Org Biomol Chem. (2015) Apr 7;13(13):3988-4001.

doi: 10.1371/journal.pone.0117831. eCollection


Di-(2-ethylhexyl) phthalate metabolites in urine show age-related changes and associations with adiposity and parameters of insulin sensitivity in childhood.

Smerieri A, Testa C, Lazzeroni P, Nuti F, Grossi E, Cesari S, Montanini L, Latini G, Bernasconi S, Papini AM, Street ME. PLoS One (2015) Feb 23;10(2):e0117831.

doi: 10.1021/jm5017126. Epub Jan 26


Synthetic peptides reproducing tissue transglutaminase-gliadin complex neo-epitopes as probes for antibody detection in celiac disease patients' sera.

Di Pisa M, Pascarella S, Scrima M, Sabatino G, Real-Fernández F, Chelli M, Renzi D, Calabrò A, D'Ursi AM, Papini AM, Rovero P. J Med Chem. (2015) Feb 12;58(3):1390-9.

doi: 10.1016/j.jinorgbio.2014.01.009


Insights on the mechanism of thioredoxin reductase inhibition by Gold N-heterocyclic carbene compounds using the synthetic linear Selenocysteine containing C-terminal peptide hTrxR(488-499): An ESI-MS investigation.

A. Pratesi, C. Gabbiani, E. Michelucci, M. Ginanneschi, A.M. Papini, R. Rubbiani, I. Ott, L. Messori. J.Inorg.Biochem. (2014) 136, 161-169.

doi: 10.1074/jbc.M113.524462


Molecular analysis of an alternative N-glycosylation machinery by functional transfer from Actinobacillus pleuropneumoniae to Escherichia coli.

A. Naegeli, C. Neupert, Y.-Y. Fan, C.-W. Chia-Wei Lin, K. Poljak, A.M. Papini, F. Schwarz, M. Aebi. J.Biol.Chem. (2014) 289(4):2170-2179.

doi: 10.1002/jrs.4484


SERS study of a tetrapeptide based on histidine and glycine residues, adsorbed on copper/silver colloidal nanoparticles.

C. Gellini, G. Sabatino, A.M. Papini, and M. Muniz-Miranda. J.Raman Spectrosc. (2014), 45(6), 418-423.

doi: 10.1002/psc.2650


Epitope Mapping of the N-terminal Portion of Tissue Transglutaminase Protein Antigen to Identify Linear Epitopes in Celiac Disease.

M. Di Pisa, P. Buccato, G. Sabatino, F. Real Fernández, B. Berti, F. Cocola, A.M. Papini, and P. Rovero. J.Pept.Sci. (2014) 20(9), 689-695.

doi: 10.1155/2014/260973


Immune dysfunction in Rett syndrome patients revealed by high levels of serum anti-N(Glc) IgM antibody fraction.

A.M. Papini, F. Nuti, F. Real-Fernandez, G. Rossi, C. Tiberi, G. Sabatino, S. Pandey, S. Leoncini, C. Signorini, A. Pecorelli, R. Guerranti, S. Lavielle, L. Ciccoli, P. Rovero, C. De Felice, and J. Hayek. J.Immunol.Res. (2014) 2014:260973.

doi: 10.1016/j.bmc.2014.10.026


Glaser Oxidative Coupling on Peptides: Stabilization of β-Turn Structure via a 1,3-Butadiyne Constraint.

N. Auberger, M. Di Pisa, M. Larregola, G. Chassaing, E. Peroni, S. Lavielle, A.M. Papini, O. Lequin, and J.M. Mallet. Bioorg.Med.Chem. (2014) 22(24), 6924-6932.

doi: 10.1002/ejoc.201402862


The Effect of Counter-ion and Tertiary Amine on the Efficiency of N-Triazinylammonium Sulfonates in Solution and Solid-Phase Peptide Synthesis.

B. Kolesinska, K.K. Rozniakowski, J. Fraczyk, I. Relich, A.M. Papini, and Z.J. Kaminski. Eur.J.O.C. (2015) 2, 401-408.

doi: 10.1021/jm501027w


1,4-Disubstituted-[1,2,3]triazolyl-Containing Analogues of MT-II: 2 Design, Synthesis, Conformational Analysis, and Biological Activity.

C. Testa, M. Scrima, M. Grimaldi, A.M. D’Ursi, M.L. Dirain, N. Lubin-Germain, A. Singh, C. Haskell-Luevano, M. Chorev, P. Rovero, and A.M. Papini. J.Med.Chem. (2014) 57(22), 9424-9434.

doi: 10.1007/s00216-012-6049-9


Analysis of egg-based model wall paintings by use of an innovative combined dot-ELISA and UPLC-based approach.

M. Potenza, G. Sabatino, F. Giambi, L. Rosi, A.M. Papini, L. Dei. Analytical and Bioanalytical Chemistry (2013) 405, 691-701.

doi: 10.1074/mcp.M112.017087


Alpha actinin is specifically recognized by multiple sclerosis autoantibodies isolated using an N-glucosylated peptide epitope.

S. Pandey, I. Dioni, D. Lambardi, F. Real-Fernandez, E. Peroni, G. Pacini, F. Lolli, R. Seraglia, A.M. Papini, P. Rovero. Mol.Cell.Proteomics. (2013) 12(2), 277-282.

doi: 10.1002/psc.2470


Evaluation of new immunological targets in neuromyelitis optica.

J.-B. Chanson, I. Paolini, N. Collongues, M.C. Alcaro, F. Blanc, F. Barbetti, M. Fleury, E. Peroni, P. Rovero, G. Rudolf, F. Lolli, E. Trifilieff, A.M. Papini, J. de Seze. J.Pept.Sci. (2013) 19(1), 25–32.

doi: 10.1016/j.bmc.2013.08.008


Divergent and convergent synthesis of polymannosylated dibranched antigenic peptide of the immunodominant epitope MBP(83-99). 

I. Friligou, F. Rizzolo, F. Nuti, T. Tselios, M. Evangelidou, M. Emmanouil, M. Karamita, J. Matsoukas, M. Chelli, P. Rovero, A.M. Papini. Bioorg.Med.Chem. (2013) 21, 6718-6725.

doi: 10.1021/jp406139t


Conformational Analysis of Gly-Ala-NHMe in D2O and DMSO Solutions: A Two-Dimensional Infrared Spectroscopy Study.

M. Candelaresi, E. Ragnoni, C. Cappelli, A. Corozzi, M. Lima, S. Monti, B. Mennucci, F. Nuti, A.M. Papini, P. Foggi. J.Phys.Chem. B (2013) 117(46), 14226-14237.



Di(2-ethylhexyl)phthalate and Autism Spectrum Disorders.

C. Testa, F. Nuti, J. Hayek, C. De Felice, M. Chelli, P. Rovero, G. Latini, A.M. Papini. ASN NEURO (American Society for Neurochemistry) (2012) 4(4), 223-229. Open Access.



Glycopeptide-Based Antibody Detection in Multiple Sclerosis by Surface Plasmon Resonance.

F. Real-Fernández, I. Passalacqua, E. Peroni, M. Chelli, F. Lolli, A.M. Papini, P. Rovero. Sensors (2012) 12, 5596-5607. Open Access.

doi: 10.1021/jp301442n


Conformational Landscape of N-Glycosylated Peptides Detecting Autoantibodies in Multiple Sclerosis, Revealed by Hamiltonian Replica Exchange.

C. Guardiani, G.F. Signorini, R. Livi, A.M. Papini, P. Procacci. J.Phys.Chem. B (2012) 116(18), 5458-5467.

doi: 10.1021/jm301031r


Designed glucopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis.

S. Pandey, M.C. Alcaro, M. Scrima, E. Peroni, I. Paolini, S. Di Marino, F. Barbetti, A. Carotenuto, E. Novellino, A.M. Papini, A.M. D'Ursi, P. Rovero. J.Med.Chem., 55(23), 10437-10447.

doi: 10.1002/psc.1395


Conventional and microwave-assisted SPPS approach: a comparative synthesis of PTHrP(1-34)NH2.         

F. Rizzolo, C. Testa, D. Lambardi, M. Chorev, M. Chelli, P. Rovero, A.M. Papini. J.Pept.Sci. (2011) 17, 708-714.

doi: 10.1016/j.jneuroim.2010.11.011


IgG and IgM antibodies to the refolded MOG1-125 extracellular domain in humans.

F. Gori, B. Mulinacci, L. Massai, C. Avolio, M. Caragnano, E. Peroni, S. Lori, M. Chelli, A.M. Papini, P. Rovero, F. Lolli. J.Neuroimmunol. (2011) 233, 216-220.

doi: 10.1021/jm1005868


Novel Octreotide Dicarba-analogues with High Affinity and Different Selectivity for Somatostatin Receptors.

A. Di Cianni, A. Carotenuto, D. Brancaccio, E. Novellino, J.C. Reubi, K. Beetschen, A.M. Papini, M. Ginanneschi. J.Med.Chem. (2010) 53, 16, 6188-6197.

Cosmetics towards peptide-based cosmeceutics.

A.M. Papini. Chimica OGGI/CHEMISTRY TODAY (2010) 28, 6, 3.

doi: 10.1002/bip.21456


Post-translationally modified peptides efficiently mimicking neo-antigens: a challenge for theragnostics of autoimmune diseases.

F. Nuti, E. Peroni, F. Real-Fernández, M.A. Bonache, A. Le Chevalier-Isaad, M. Chelli, N. Lubin-Germain, J. Uziel, P. Rovero, F. Lolli, A.M. Papini. Biopolymers (2010) 94(6), 791-799.

L-Lactide Polymerization by Calix[4]arene-Titanium (IV) Complex Using Conventional Heating and Microwave Irradiation.

M. Frediani, D. Sémeril, D. Matt, F. Rizzolo, A.M. Papini, P. Frediani, L. Rosi, M. Santella, and G. Giachi. e-Polymers (2010) 19, 1-8.

Ring Opening Polymerization of rac-Lactide using a calix[4]arene-based Titanium (IV) Complex.

M. Frediani, D. Sémeril, D. Matt, F. Rizzolo, A.M. Papini, P. Frediani, and L. Rosi. International Journal of Polymer Science (2010) 1-6.

doi: 10.1007/s00726-010-0484-8


Microwave-assisted reaction of glycosylamine with aspartic acid.

F. Real-Fernández, F Nuti, M.A. Bonache, M. Boccalini, S. Chimichi, M. Chelli, AM. Papini. Amino Acids (2010) 39, 599-604.

doi: 10.1002/psc.1166


The use of post-translationally modified peptides for detection of biomarkers of immune-mediated diseases.

A.M. Papini. J.Pept.Sci. (2015) 15(10), 621-628.

doi: 10.1002/psc.1141


Side chain-to-side chain cyclization by click reaction.

A. Le Chevalier-Isaad, A.M. Papini, M. Chorev, P. Rovero. J.Pept.Sci. (2009), 15(7), 451-454.

doi: 10.1016/j.tetlet.2009.04.124


Synthesis of new ribosylated Asn building blocks as useful tools for glycopeptide and glycoprotein synthesis.

M. Angeles Bonache, F. Nuti, A. Le Chevalier-Isaad, F. Real-Fernandez, M. Chelli, P. Rovero, A.M. Papini. Tetrahedron Letters (2009) 50(28), 4151-4153.

Towards peptide-based diagnostics.

A.M. Papini. Chimica Oggi-Chemistry Today (2009), 27, 2, 2.

Peptide contribution to the diagnosis of autoimmune diseases.

M.C. Alcaro, I. Paolini, F. Lolli, P. Migliorini, P. Rovero, and A.M. Papini. Chimica Oggi-Chemistry Today (2009) 27(2), 11-14.

doi: 10.1002/psc.1105


Building Blocks for the Synthesis of Post-Translationally Modified Glycated Peptides and Proteins.

S. Carganico, P. Rovero, J.A. Halperin, A.M. Papini, M. Chorev. J.Pept.Sci. (2009) 15, 67-71.

doi: 10.1021/jo800142s


Synthesis and Conformational Analysis of a Cyclic Peptide Obtained via i-to-i+4 Intramolecular Side-Chain-to-Side-Chain Azide–Alkyne 1,3-Dipolar Cycloaddition.

S. Cantel, A. Le Chevalier-Isaad, M. Scrima, J.J. Levy, R.D. DiMarchi, P. Rovero, J.A. Halperin, A.M. D'Ursi, A.M. Papini, M. Chorev. J.Org.Chem. (2008) 73, 5663-5674.

doi: 10.1021/jm800391y


Designed glycopeptides with different beta-turn types as synthetic probes for the detection of autoantibodies as biomarkers of multiple sclerosis.

A. Carotenuto, M.C. Alcaro, M.R. Saviello, E. Peroni, F. Nuti, A.M. Papini, E. Novellino, P. Rovero. J.Med.Chem. (2008) 51(17), 5304–5309.

doi: 10.1021/jm070886i


Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships.

D. D’Addona, A. Carotenuto, E. Novellino, V. Piccand, J.C. Reubi, A. Di Cianni, F. Gori, A.M. Papini, M. Ginanneschi. J.Med.Chem. (2008) 51(3), 512–520.

doi: 10.1002/ejoc.200800717


N(alpha)-Fmoc-Protected ω-Azido- and ω-Alkynyl-L-amino Acids as Building Blocks for the Synthesis of “Clickable” Peptides.

A. Le Chevalier-Isaad, F. Barbetti, P. Rovero, A.M. D’Ursi, M. Chelli, M. Chorev, A.M. Papini. Eur.J.Org.Chem. (2008) 31, 5308-5314.

doi: 10.1002/bip.20955


Ferrocenyl glycopeptides as electrochemical probes to detect autoantibodies in multiple sclerosis patients’ sera.

F. Real-Fernández, A. Colson, J. Bayardon, F. Nuti, E. Peroni, R. Meunier-Prest, F. Lolli, M. Chelli, C. Darcel, S. Jugé, A.M. Papini. Biopolymers (2008) 90(4), 488–495.

Advances in automatic, manual and microwave-assisted solid-phase peptide synthesis.

G. Sabatino, and A.M. Papini. Current Opinion in Drug Discovery & Development (2008) 11, 762–770.

Optimized strategies for the synthesis of biomolecules by the microwave approach.

I. Paolini, F. Rizzolo, and A.M. Papini. Supplement to Chimica Oggi-Chemistry Today (2008) 26(3), 16-18.

A convenient microwave-enhanced solid-phase synthesis of difficult peptide sequences: case study of Gramicidin A and CSF114(Glc).

F. Rizzolo, G. Sabatino, M. Chelli, P. Rovero, and A.M. Papini. Int.J.Pept.Res.Ther. (2007) 13, 1-2, 203-208.

A convenient microwave-assisted synthesis of N-glycosyl amino acids.

I. Paolini, F. Nuti, M.C. Pozo-Carrero, F. Barbetti, B. Kolesinska, Z.J. Kaminski, M. Chelli, and A.M. Papini. Tetrahedron Letters (2007) 48, 2901-2904.

ISSN: 0968-0896.


Fmoc-protected iminosugar modified asparagine derivatives as building blocks for glycomimetics-containing peptides.

F. Nuti, I. Paolini, F. Cardona, M. Chelli, F. Lolli, A. Brandi, A. Goti, P. Rovero, and A.M. Papini. Bioorg.Med.Chem. (2007) 15(12), 3965-3973.

Peptides as autoimmune diseases antigenic probes: a peptide-based reverse approach to detect biomarkers of autoimmune diseases.

M.C. Alcaro, F. Lolli, P. Migliorini, M. Chelli, P. Rovero, and A.M. Papini. Chimica Oggi-Chemistry Today (2007) 25(3), 14-16.

doi: 10.1073/pnas.0706426104


Electrostatic interactions in phospholipid membranes revealed by coherent two-dimensional infrared spectroscopy.

V.V. Volkov, R. Chelli, W. Zhuang, F. Nuti, Y. Takaoka, A.M. Papini, S. Mukamel, and R. Righini. Proc.Natl.Acad.Sci. USA (2007) 104, 15323-15327.

Benzyloxy derivatives of triazine-based coupling reagents designed for an efficient solid phase peptide synthesis on polystyrene resin

K. Jastrzabek, B. Kolesinska, G. Sabatino, F. Rizzolo, A.M. Papini, and Z.J. Kaminski. Int.J.Pept.Res.Ther. (2007) 13, 1-2, 229-236.

Sulfonates of N-triazinylammonium salts as highly efficient, inexpensive and environmentally friendly coupling reagents for peptide synthesis.

B. Kolesinska, J. Fraczyk, G. Sabatino, A.M. Papini, and Z.J. Kaminski. Chimica Oggi-Chemistry Today (2007) 25(1), 10-13.

 doi: 10.1002/cmdc.200500010


Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition.

F. Minutolo, S. Bertini, L. Betti, R. Danesi, G. Gervasi, G. Giannaccini, A. Martinelli, A.M. Papini, E. Peroni, G. Placanica, S. Rapposelli, T. Tuccinardi, and M. Macchia. CHEMMEDCHEM (2006) 1(2), 218-224.

doi: 10.1002/cbic.200500390


Development of antiviral fusion inhibitors: short modified peptides derived from the transmembrane glycoprotein of feline immunodeficiency virus.

A.M. D’Ursi, S. Giannecchini, C. Esposito, M.C. Alcaro, O. Sichi, M.R. Armenante, A. Carotenuto, A.M. Papini, M. Bendinelli, and P. Rovero. CHEMBIOCHEM (2006) 7(5), 774-779.

Bradykinin antagonists modified with dipeptide mimetic b-turn inducers.

M.C. Alcaro, V. Vinci, A.M. D’Ursi, M. Scrima, M. Chelli, S. Giuliani, S. Meini, M. Di Giacomo, L. Colombo, and A.M. Papini. Bioorg.Med.Chem.Lett. (2006) 16, 2387-2390.

M.C. Alcaro, and A.M. Papini


Contribution of peptides to Multiple Sclerosis research

Biopolymers: Peptide Science 84, pp 349-367.

V.V. Volkov, F. Nuti, Y. Takaoka, R. Chelli, A.M. Papini, and R. Righini


Hydration and hydrogen bonding of carbonyls in dimyristoyl-phospahtidylcholine bilayer

J. Am. Chem. Soc. 128, pp 9466-9471

A. Carotenuto, A.M. D’Ursi, B. Mulinacci, I. Paolini, F. Lolli, A.M. Papini, E. Novellino, and P. Rovero


Conformation-activity relationship of designed glycopeptides as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis

J. Med. Chem. 49, pp 5072-5079.

F. Lolli, P. Rovero, M. Chelli, and A.M. Papini. 


Toward biomarkers in multiple sclerosis: new advances

Expert Rev. Neurotherapeutics 6, pp 781-794.

A. Carotenuto, D. D’Addona, E. Rivalta, M. Chelli, A.M. Papini, P. Rovero, and M. Ginanneschi


Synthesis of a dicarba-analogue of octreotide keeping the type II’ b-turn of the pharmacophore in water solution

Lett. Org. Chem. 2, pp 274-279.

J. Matsoukas, V. Apostolopoulos, H. Kalbacher, A.M. Papini, T. Tselios, K. Chatzantoni, T. Biagioli, F. Lolli, S. Deraos, P. Papathanassopoulos, A. Troganis, E. Mantzourani, T. Mavromoustakos, and A. Mouzaki


Design and synthesis of a novel potent myelin basic protein epitope 87-99 cyclic analogue: enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators

J. Med. Chem. 48, pp 1470-1480.

F. Nuti, S. Hildenbrand, M. Chelli, R. Wodarzb, and A.M. Papini


Synthesis of DEHP metabolites as biomarkers for GC-MS evaluation of phthalates as endocrine disrupters

Bioorg. Med. Chem. 13, pp 3461-3465.

A.M. Papini


Simple test for Multiple Sclerosis

Nature Medicine 11(1), p 13.

F. Lolli, B. Mulinacci, A. Carotenuto, B. Bonetti, G. Sabatino, B. Mazzanti, A.M. D’Ursi, E. Novellino, M. Pazzagli, L. Lovato, M.C. Alcaro, E. Peroni, M.C. Pozo-Carrero, F. Nuti, L. Battistini, G. Borsellino, M. Chelli, P. Rovero, and A.M. Papini


An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of Multiple Sclerosis

Proc. Natl. Acad. Sci., U.S.A. 102(29), pp 10273-10278.

F. Lolli, B. Mazzanti, M. Pazzagli, E. Peroni, M.C. Alcaro, R. Lanzillo, V. Brescia Morra, L. Santoro, C. Gasperini, S. Galgani, M.M. D’ Elios, V. Zipoli, S. Sotgiu, M. Pugliatti, P. Rovero, M. Chelli, and A.M. Papini


The glycopeptide CSF114(Glc) detects serum antibodies in Multiple Sclerosis

J. Neuroimmunol. 167(1-2), pp 131-137.

S. Giannecchini, M.C. Alcaro, P. Isola, O. Sichi, M. Pistello, A.M. Papini, P. Rovero, and M. Bendinelli 


Feline immunodeficiency virus plasma load reduction by a retroinverso octapeptide reproducing the Trp-rich motif of the transmembrane glycoprotein

Antiviral Therapy 10, pp 671-680.

F. Lolli, P. Rovero, M. Chelli, and A.M. Papini


Antibodies against glycosylated native MOG are elevated in patients with Multiple Sclerosis

Neurology 65(5), pp 781-782.

Z.J. Kaminski, B. Kolesinska, J. Kolesinska, G. Sabatino, M. Chelli, P. Rovero, M. Baszczyk, M.L. Gowka, and A.M. Papini


 N-triazinylammonium tetrafluoroborates. A new generation of efficient coupling reagents useful for peptide synthesis

J. Am. Chem. Soc., 127,pp 16912-16920.

doi: 10.1002/psc.512


On-resin head-to-tail cyclization of cyclotetrapeptides: optimization of crucial parameters.

M.C. Alcaro, G. Sabatino, J. Uziel, M. Chelli, M. Ginanneschi, P. Rovero, A.M. Papini. J.Pept.Sci. (2004) 10(4), 218-228.

M.C. Alcaro, G. Sabatino, J. Uziel, M. Chelli, M. Ginanneschi, P. Rovero, and A.M. Papini


On-resin head-to-tail cyclization of cyclotetrapeptides: optimization of crucial parameters

J. Peptide Science 10, pp 218-228.

F. Meyer, A. Laaziri, A.M. Papini, J. Uziel, and S. Jugé 


A novel phosphorus-carbon bond formation by ring opening with diethyl phosphite of oxazolines derived from serine

Tedrahedron 60, pp 3593-3597.

F. Machetti, F.M. Cordero, F. De Sarlo, A.M. Papini, M.C. Alcaro, and A. Brandi


Synthesis of free and Na -Fmoc/Na-Boc protected (2S, 4S)- and (2S, 4R)-4-aminopipecolic acids

Eur. J. Org. Chem. 13, pp 2928-2935.

doi: 10.1021/jm049692i


Carbonic anhydrase inhibitors: The first on-resin screening of a 4-sulfamoylphenylthioureas library.

A. Innocenti, A. Casini, M.C. Alcaro, A.M. Papini, A. Scozzafava, and C.T. Supuran. J.Med.Chem. (2004) 47(21), 5224-5229.

doi: 10.1007/b93987


Photophysical investigation of lipopeptides of myelin basic protein in phospholipid vesicles.

G. Caminati, E. Peroni, A.M. Papini, and P. Baglioni. Progr.Colloid Polym.Sci. (2004) 126, 163-168.

doi: 10.2174/1385272043485954


Analytical methods for solid phase peptide synthesis.

G. Sabatino, M. Chelli, A. Brandi, and A.M. Papini. Current Organic Chemistry (2004) 8(4), 291-301.

doi: 10.2174/1389203033487117


Synthetic peptides in the diagnosis of HIV infection.

M.C. Alcaro, E. Peroni, P. Rovero, and A.M. Papini. Current Protein and Peptide Science (2003) 4(4), 285-290.

doi: 10.2174/1389203033487162


Synthetic peptides in the diagnosis of neurological diseases.

F. Lolli, B. Mazzanti, P. Rovero, and A.M. Papini. Current Protein and Peptide Science (2003) 4(4), 277-284.